Table 1.
Effects of acute administration of imperatorin (IMP; 1, 5, and 10 mg/kg) and rivastigmine (RIVA; 0.5 mg/kg, i.p) on the memory acquisition or consolidation trials using the PA test in mice. Appropriate groups of mice received saline, imperatorin (1, 5, or 10 mg/kg, i.p.), or rivastigmine (RIVA; 0.5 mg/kg, i.p) before the pretest (acquisition) or after the pretest (consolidation). Data represent the means ± SEM and are expressed as latency index (IL); n = 8–12; *p < 0.05, **p < 0.01, ***p < 0.001 versus saline-treated group; Tukey’s test
saline | RIVA | IMP | IMP | IMP | F | p value | |
---|---|---|---|---|---|---|---|
0.5 mg/kg | 1 mg/kg | 5 mg/kg | 10 mg/kg | ||||
ACQUISITION | |||||||
IL | 2.180 ± 0.294 | 8.200 ± 0.204*** | 2.854 ± 0.396 | 4.847 ± 0.350* | 4.999 ± 0.188** | F(4,39) = 6.008 | 0.0009 |
CONSOLIDATION | |||||||
IL | 2.389 ± 0.129 | 7.201 ± 1.845*** | 1.530 ± 0.388 | 4.352 ± 0.384* | 4.701 ± 0.338** | F(4,38) = 6,024 | 0.0009 |