Table 3.
Effect of subchronic administration of imperatorin (IMP; 1, 5, or 10 mg/kg, i.p.) and single scopolamine injection (SCP; 1 mg/kg i.p.) on the seventh day, separately or jointly, on activity of SOD in the whole brain, cortex and hippocampus of mice. Data are presented as the means ± SEM; n = 8–12; ***p < 0.001 versus saline-treated control group, # p < 0.05 versus scopolamine-treated control group; Tukey’s test
| Treatment | SOD [U/mg protein] | ||
|---|---|---|---|
| Brain | Cortex | Hippocampus | |
| Saline | 2.78 ± 0.09 | 13.86 ± 0.89 | 12.97 ± 0.73 |
| SCP | 2.38 ± 0.14 | 9.68 ± 0.75*** | 9.38 ± 0.46*** |
| IMP 1 mg/kg | 2.96 ± 0.15 | 13.65 ± 0.29 | 11.06 ± 0.53 |
| IMP 1 mg/kg + SCP | 2.43 ± 0.16 | 12.38 ± 0.65# | 9.76 ± 0.59 |
| IMP 5 mg/kg | 2.79 ± 0.16 | 13.41 ± 0.60 | 11.49 ± 0.61 |
| IMP 5 mg/kg + SCP | 2.49 ± 0.19 | 12.88 ± 0.46# | 11.00 ± 0.22 |
| IMP 10 mg/kg | 2.89 ± 0.17 | 13.87 ± 0.61 | 11.97 ± 0.83 |
| IMP 10 mg/kg + SCP | 2.62 ± 0.17 | 13.29 ± 0.33# | 12.10 ± 0.88# |