Table 4.
Effect of repeated administration of imperatorin (IMP; 1, 5, or 10 mg/kg, i.p.) and single scopolamine injection (SCP; 1 mg/kg, i.p.) on the seventh day, separately or jointly, on activity of GPx in the whole brain, cortex and hippocampus of mice. Data are presented as the means ± SEM; n = 8–12; ***p < 0.001 versus saline-treated control group, # p < 0.05, ## p < 0.01 versus scopolamine-treated control group; Tukey’s test
| Treatment | GPx [U/g protein] | ||
|---|---|---|---|
| Brain | Cortex | Hippocampus | |
| Saline | 15.87 ± 0.55 | 64.29 ± 1.88 | 62.48 ± 2.88 |
| SCP | 10.07 ± 1.01*** | 48.01 ± 2.49*** | 32.91 ± 2.27*** |
| IMP 1 mg/kg | 12.99 ± 0.45 | 65.66 ± 2.65 | 62.14 ± 2.19 |
| IMP 1 mg/kg + SCP | 11.26 ± 0.99 | 53.93 ± 2.62 | 32.40 ± 3.21 |
| IMP 5 mg/kg | 14.91 ± 0.93 | 67.29 ± 4.42 | 55.03 ± 4.00 |
| IMP 5 mg/kg + SCP | 12.38 ± 0.87 | 67.94 ± 1.50## | 41.56 ± 2.24 |
| IMP 10 mg/kg | 15.77 ± 0.96 | 63.36 ± 4.70 | 61.68 ± 2.99 |
| IMP 10 mg/kg + SCP | 13.42 ± 0.49 | 63.36 ± 4.17# | 52.00 ± 3.47## |