Table 5.
Effect of repeated administration of imperatorin (IMP; 1, 5, or 10 mg/kg, i.p.) and single scopolamine injection (SCP; 1 mg/kg, i.p.) on the seventh day, separately or jointly, on activity of GR in the cortex and hippocampus of mice. Data are presented as the means ± SEM; n = 8–12, ***p < 0.001 versus saline-treated control group; # p < 0.05 versus scopolamine-treated control group; Tukey’s test
| Treatment | GR [U/g protein] | |
|---|---|---|
| Cortex | Hippocampus | |
| Saline | 53.29 ± 4.78 | 98.73 ± 3.15 |
| SCP | 34.63 ± 12.95*** | 78.63 ± 2.86*** |
| IMP 1 mg/kg | 46.87 ± 1.22 | 90.01 ± 4.63 |
| IMP 1 mg/kg + SCP | 35.38 ± 1.48 | 77.80 ± 2.05 |
| IMP 5 mg/kg | 51.46 ± 2.46 | 95.13 ± 3.91 |
| IMP 5 mg/kg + SCP | 41.48 ± 1.62 | 76.89 ± 4.59 |
| IMP 10 mg/kg | 52.61 ± 2.39 | 93.40 ± 2.83 |
| IMP 10 mg/kg + SCP | 46.93 ± 1.91# | 82.16 ± 4.06 |