Fig. 2.

Endothelin-3 (ET-3) signaling shifted the [Na⁺]_o dependency of Na_x activation to the lower side. a Relationships between the current density and [Na⁺]_o in the presence or absence of 1 nM ET-3; n = 6 for each. b In situ hybridization for detection of ET-3 expression in the SFO of WT mice. Brains were obtained from mice provided freely with food and water (0 h) or from those provided only with food during the indicated period (12, 24, 36, and 48 h). Sections on the same slide are shown. c Activation cascades of Na_x by ET_BR signaling. The pathway indicated by dotted lines was suggested not to work for the Na_x activation. Reproduced with permission from [35]