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. 2015 Feb 12;5:8412. doi: 10.1038/srep08412

Figure 7. Regulation of hmsCDE transcription by Rcs in Y. pseudotuberculosis and Y. pestis.

Figure 7

In Y. pseudotuberculosis (top), RcsB together with RcsA indirectly repress the transcription of hmsCDE independent of the RcsAB binding site, while RcsB activates transcription of hmsCDE dependent on the RcsB binding site. As a consequence, Rcs negatively regulates the hmsCDE operon in Y. pseudotuberculosis. In Y. pestis (bottom), as rcsA is mutated to nonfunctional pseudogene, RcsB alone directly positively but indirectly negatively regulates hmsCDE operon. As a consequence, Rcs positively regulates the hmsCDE operon in Y. pestis.