Table 1.
Physical data and AChE inhibitory activity of naphthyridines (4a–k).
| Entry | Product | Reaction time (min) | Yield (%) |
mp °C | AChE inhibition (IC50 ± SD) mol/L |
|---|---|---|---|---|---|
| 1 |
|
8 | 75 | 211-212 | 11.18 ± 0.02 |
|
| |||||
| 2 |
|
7 | 72 | 229-230 | 7.20 ± 0.02 |
|
| |||||
| 3 |
|
7 | 76 | 220-221 | 15.21 ± 0.1 |
|
| |||||
| 4 |
|
6 | 70 | 208-209 | 18.16 ± 0.02 |
|
| |||||
| 5 |
|
9 | 67 | 215-216 | 2.12 ± 0.02 |
|
| |||||
| 6 |
|
6 | 72 | 225-226 | 24.72 ± 0.01 |
|
| |||||
| 7 |
|
6 | 70 | 206-207 | 16.86 ± 0.02 |
|
| |||||
| 8 |
|
7 | 73 | 235-236 | 7.16 ± 0.02 |
|
| |||||
| 9 |
|
6 | 78 | 221-222 | 3.86 ± 0.02 |
|
| |||||
| 10 |
|
7 | 74 | 218-219 | 14.16 ± 0.02 |
|
| |||||
| 11 |
|
10 | 65 | 204-205 | 6.86 ± 0.02 |
|
| |||||
| 12 | Galantamine.HBr | — | — | — | 2.09 ± 0.02 |