Table 3.

Multivariable regression models of overall mean systolic blood pressure with white matter hyperintensity and fractional anisotrophy of uncinate and superior longitudinal fasciculi, adjusted for age, stroke, and antihypertensive medication use

	WMH greater than or equal to the median, odds ratio (95% CI)a	FA, standardized beta (SE)b
Independent variable, overall mean SBP of 10mm Hg	10.4 (10.2–10.6) P < 0.0001	−13.54 (4.58) P = 0.003

Odds ratio and standardized beta are for 10mm Hg of overall mean systolic blood pressure (SBP). Mean (SD) of fractional anisotrophy (FA) for these tracts in this population is 2.29 (0.12). Therefore, 13.54 in standardized units of FA corresponds to a difference of 1.62 in FA.

Abbreviations: CI, confidence interval; WMH, white matter hyperintensity

^aFrom logistic regression model with presence of WMH as the dependent variable.

^bFrom linear regression model with FA as dependent variable.