Table 4.

Multivariable regression models of group-based trajectories of systolic blood pressure with white matter hyperintensity of uncinate fasciculus and fractional anisotrophy of superior longitudinal fasciculus, adjusted for age, stroke, and antihypertensive medication use

Independent variable: group trajectories of SBP	WMH greater than or equal to the median, odds ratio, (95% CI)a	FA, standardized beta (SE)b
1: Normal SBP at time of neuroimaging (<120mm Hg), previously stable	Referent	Referent
2: Moderate SBP at time of neuroimaging (120–140mm Hg), previously stable	2.2 (1.1–4.2)	0.035 (0.162)
3. Moderate SBP at time of neuroimaging (120–140mm Hg), previously higher and varying	3.0 (1.4–6.4)	−0.585 (0.305)
4: High SBP at time of neuroimaging (>140 and ≤120mm Hg), previously stable	2.7 (0.8–8.9)	−0.383 (0.192)
5. High SBP at time of neuroimaging (>140 and ≤120mm Hg), previously higher and varying	8.6 (2.0–36.7)	−0.431 (0.321)
P value	0.02	0.01

Abbreviations: CI, confidence interval; FA, fractional anisotropy; SBP, systolic blood pressure; WMH, White matter hyperintensity.

^aLogistic regressions with presence of WMH as the dependent variable.

^bGeneralized linear models with FA as dependent variable.