TABLE 3.

Pathway Express analysis of the host response to IBDV infection in the spleen

Rank	Pathway	Impact factor	Input genes/genes in pathway	Corrected gamma P value
1	Leukocyte transendothelial migration	41.149	12/119	5.68E–17
2	Cell adhesion molecules (CAMs)	30.238	14/134	2.30E–12
3	Phosphatidylinositol signaling system	23.129	1/76	2.18E–09
4	Cytokine-cytokine receptor interaction	17.66	39/263	3.99E–07
5	Circadian rhythm	12.371	1/13	5.67E–05
6	Jak/STAT signaling pathway	9.513	23/155	7.77E–04
7	Toll-like receptor signaling pathway	7.164	17/102	0.006318549
8	Graft-versus-host disease	6.712	4/42	0.00937956
9	Regulation of autophagy	6.442	1/35	0.011856721
10	Proteasome	6.319	1/48	0.013186967
11	TGF-β signaling pathway	6.093	5/87	0.016020412
12	Complement and coagulation cascades	6.064	10/69	0.016424379
13	Neuroactive ligand-receptor interaction	4.986	14/256	0.040901989
14	Antigen processing and presentation	4.647	7/89	0.054156592
15	Axon guidance	4.491	14/129	0.061550973
16	Type I diabetes mellitus	4.456	3/44	0.063337096
17	Systemic lupus erythematosus	4.425	8/144	0.064960096
18	Allograft rejection	4.361	3/38	0.068436465
19	Epithelial cell signaling in Helicobacter pylori infection	4.348	12/68	0.069163823
20	Hematopoietic cell lineage	4.294	13/87	0.072264239
21	Type II diabetes mellitus	4.231	5/45	0.076047469
22	Apoptosis	4.198	13/89	0.078103058
23	Natural killer cell mediated cytotoxicity	4.168	10/135	0.080017155
24	Basal cell carcinoma	3.776	2/55	0.109438052
25	ABC transporters	3.54	7/44	0.131720505
26	Adipocytokine signaling pathway	3.205	7/67	0.170550181
27	Adherens junction	3.05	4/78	0.191803644
28	Renal cell carcinoma	2.845	10/69	0.223526256
29	Mitogen-activated protein signaling pathway	2.758	22/272	0.238326642
30	Long-term depression	2.695	6/75	0.249569101