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. 2014 Dec 17;89(5):2710–2717. doi: 10.1128/JVI.03346-14

FIG 4.

FIG 4

Spread of hyperfusogenic viruses in the brains and spleens of SLAM knock-in mice. (A) Spread of EGFP-expressing viruses in the brains of infected IFNAR−/− SLAM knock-in mice. Four mice were infected with 104 PFU of IC323-EGFP, IC323-F(T461I)-EGFP, or IC323-F(S103I/N462S/N465S)-EGFP (Triple), intracerebrally. At 6 days p.i., the brains of euthanized mice were observed under a fluorescent stereomicroscope. Light and EGFP images of the brains were photographed, and top and sagittal views are shown. (B) Eight IFNAR−/− SLAM knock-in mice were inoculated intraperitoneally with 1.5 × 105 PFU of IC323-Luci or IC323-F(T461I)-Luci. At 7 days p.i., the spleens were removed and analyzed for their Renilla luciferase activities. Each circular symbol indicates the sample from a single mouse; bars indicate the mean values, and asterisks indicate statistically significant difference (P < 0.05). RLU, relative light unit.