TABLE 1.
Survival of BALB/c and C57BL/6 mice after ocular challenge with gK recombinant virusesa
| Virus | Mouse survival after virus infection at various doses (PFU/eye) |
LD50 (PFU) | ||||
|---|---|---|---|---|---|---|
| 2 × 106 | 2 × 105b | 2 × 104 | 2 × 103 | 2 × 102 | ||
| NgK | 4/5 | 12/12, 0/5 | 1/5 | 5/5 | 5/5 | 15,642 |
| MgK | 5/5 | 12/12, 4/5 | 4/5 | 5/5 | 5/5 | 2,115,650 |
| RgK | 5/5 | 10/10, 1/5 | 2/5 | 5/5 | 5/5 | 27,660 |
a
Mice were challenged ocularly with the specified amount of each virus, and survival was determined 28 days after challenge. All of the mice were BALB/c mice except as noted in column 3. Mouse survival is presented as the number of mice surviving/the number of mice tested.
b
The survival data in this column are presented for two mouse strains: C57BL/6, BALB/c.