TABLE 1.
Summary of key in vitro activities of VX-787 with influenza virus type A reference strain A/Puerto Rico/8/34a
| Assay | Mean assay result (nM), no. of expts |
|---|---|
| CPE (ATP) (VX-787 EC50) | 1.6 ± 0.77, n = 16 |
| Viral RNA (bDNA) (VX-787 EC50) | 2.6 ± 0.88, n = 11 |
| Viral RNA (bDNA) (VX-787 EC99) | 11 ± 9.2, n = 10 |
| Cytotoxicity (ATP) (VX-787 CC50) | ≥10,000 ± ND, n = 6 |
a
Data shown represent means ± standard deviations of the results of n independent experiments. EC50, effective concentration at which the ATP or viral RNA level is half the maximum; bDNA, branched DNA; EC99, effective concentration at which the viral RNA level is 99% maximum; CC50, concentration at which the cytopathic effect, as measured by ATP levels, is half the maximum in the 3-day CPE-based assay; ND, not determined.