TABLE 4.

Predictive peramivir PK/PD in the upper respiratory tract

Administration regimena	AUCb (nM · h)c	Predicted % time (h) above ICd at required peramivir concn in the upper respiratory tract atc:
		50 nM	100 nM	200 nM	300 nM
1	109,103	100	100	90.7 (108.9)e	76.8 (92.2)e
2	113,439	78.6 (94.3)e	67.1 (80.5)e	55.6 (66.7)e	48.9 (58.7)e
3	216,254	100	100	100	97.8 (117.4)e
4	224,383	87.4 (104.9)e	76.3 (91.5)e	65.2 (78.2)e	58.7 (70.4)e

^aRegimen 1, 5 mg/kg every 12 h for 5 days; regimen 2, 10 mg/kg every 24 h for 5 days; regimen 3, 10 mg/kg every 12 h for 5 days; and regimen 4, 20 mg/kg every 24 h for 5 days.

^bAUC, area under the concentration-time curve.

^cFrom 0 to 120 h after the initial peramivir administration.

^dIC, inhibitory concentration.

^eDuration above the IC from 0 to 120 h after the initial administration of peramivir.