FIG 2.

Effect of increasing concentrations of carbapenems on biofilm viability in K. pneumoniae. Cells were grown for 24 h in LB and then incubated with the indicated fold increases of carbapenems over the MIC. (A) After 2 h of treatment, there were significant decreases in viability with 100× and 1,000× imipenem, 1,000× meropenem, and 10×, 100×, and 1,000× doripenem. (B) After 24 h of treatment, there were significant decreases in viability with all three drugs at all three increased concentrations. *, P < 0.05; **, P < 0.01; ***, P < 0.001.