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Dasabuvir EC50 values against stable subgenomic replicon cell lines
| HCV replicon subtype | EC50 (mean ± SD) (nM)a |
|
|---|---|---|
| With 0% human plasma | With 40% human plasma | |
| Genotype 1a (H77) | 7.7 ± 3.8 | 99 ± 13 |
| Genotype 1b (Con1) | 1.8 ± 0.98 | 21 ± 10 |
The EC50s and SDs were calculated from at least 3 experiments conducted in duplicate. Both the 0% and 40% human plasma assays also contained 5% fetal bovine serum.
