TABLE 2.
Pfmspdbl1 SNPs significantly associated with drug responses to chloroquine and lumefantrine
| Codon(s) | SNP(s) | Nucleotide(s) (amino acid[s])a | Chloroquine |
Lumefantrine |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n (%) | Median IC50 (nM) | 95% CI | P value | n (%) | Median IC50 (nM) | 95% CI | P value | |||
| 351, 354 | 1051, 1060 | G, A (DK) | 12 (32) | 14.7 | 12.6–31.5 | 12 (32) | 206 | 52.4–344.9 | ||
| A, G (NE) | 25 (68) | 86.2 | 58.1–104.3 | 0.0013b | 25 (68) | 80.8 | 66.3–97.8 | 0.04b | ||
| 358, 359 | 1072, 1074, 1075, 1076 | A, C, C, A (IQ) | 14 (38) | 23.8 | 14.0–93.8 | 14 (38) | 136.8 | 66.2–334.8 | ||
| G, A, A, G (VR) | 23 (62) | 85.2 | 55.9–99.7 | 0.05b | 23 (62) | 84.6 | 53.2–102.0 | 0.04b | ||
| 361 | 1081 | T (F) | 15 (41) | 30.7 | 14.4–95.7 | 15 (41) | 111.6 | 68.9–330.0 | ||
| A (I) | 22 (59) | 85.7 | 56.4–102.3 | 0.08 | 22 (59) | 82.7 | 48.5–98.2 | 0.03b | ||
| 365 | 1093 | G (D) | 13 (36) | 16.8 | 13.3–102.1 | 13 (36) | 104.4 | 62.7–340.9 | ||
| A (N) | 23 (64) | 85.2 | 55.9–99.7 | 0.07 | 23 (64) | 84.6 | 53.2–102.0 | 0.05b | ||
| 380 | 1139 | A (E) | 14 (37) | 24.2 | 14.0–98.9 | 14 (37) | 108 | 66.2–334.8 | ||
| G (G) | 24 (63) | 84.1 | 48.2–96.1 | 0.12 | 24 (63) | 87.7 | 60.2–110.5 | 0.06 | ||
| 380, 398, 416 | 1140, 1194, 1247 | A, C, T (EGI) | 14 (38) | 24.2 | 14.0–98.9 | 14 (38) | 108 | 66.2–334.8 | ||
| T, T, G (GGR) | 23 (62) | 85.2 | 55.9–99.7 | 0.11 | 23 (62) | 84.6 | 53.2–102.0 | 0.045b | ||
| 420 | 1259 | A (K) | 15 (39) | 31.6 | 14.4–95.7 | 15 (39.5) | 111.6 | 68.9–330.0 | ||
| T (I) | 23 (61) | 85.2 | 55.9–99.7 | 0.09 | 23 (60.5) | 84.6 | 53.2–102.0 | 0.035b | ||
| 444 | 1332 | A (K) | 26 (74) | 84.1 | 31.1–99.7 | 26 (74) | 104.3 | 77.7–206.6 | ||
| T (N) | 9 (26) | 56.4 | 12.8–103.6 | 0.5 | 9 (26) | 48.6 | 36.9–93.8 | 0.03b | ||
| 631 | 1891 | A (K) | 24 (67) | 30.5 | 14.9–82.5 | 24 (67) | 100.7 | 76.9–160.3 | ||
| G (E) | 12 (33) | 103.3 | 59.2–114.9 | 0.0025b | 12 (33) | 61.8 | 36.9–270.6 | 0.17 | ||
| 669 | 2007 | T (N) | 19 (58) | 30.7 | 15.5–82.3 | 19 (58) | 97.6 | 73.3–138.1 | ||
| C (N) | 14 (42) | 106.4 | 78.6–123.8 | 0.0015b | 14 (42) | 58.1 | 38.0–240.1 | 0.19 | ||
a
The bold letters highlight the 3D7 reference alleles.
b
Significant result (P ≤ 0.05).