FIG 2.

Time-kill curve analyses for azithromycin (AZT), fosfomycin (FOS), and ceftriaxone (CRO) and their combinations. For all strains, at 24 h, the results indicated that (i) FOS was bactericidal at 2× the MIC, but at >24 h, there was regrowth of bacteria; (ii) CRO was bactericidal at 0.5× the MIC (including for strain F89); (iii) AZT was bactericidal only at 4× the MIC; (iv) CRO plus AZT was less bactericidal than CRO alone; (v) FOS plus AZT was bactericidal at 2× the MIC; (vi) CRO plus AZT and FOS plus CRO were both bactericidal at 0.5× the MIC, but FOS plus CRO had more rapid effects.