FIG 1.

Incubation of P. falciparum gametocytes with FBS0701 inhibits development in the mosquito. To analyze the effect of FBS0701 on malarial gametocytes, P. falciparum stage V gametocyte cultures were incubated with different concentrations of FBS0701 for 12, 48, and 72 h. Gametocytes were fed to A. gambiae mosquitoes, and the numbers of oocysts were determined in mosquito midguts at 7 days postinfection. (A) Representative experiment. Horizontal bars represent median oocyst numbers. FBS, FBS0701; N, number of mosquitoes; Prev, prevalence. (B) Percent inhibition of oocyst formation. The bars represent the pooled percent inhibition of oocyst formation from independent experiments tabulated in Table S1 in the supplemental material. (C) Percent reduction in prevalence. The bars represent the pooled percent reduction in prevalence (percent infected mosquitoes) compared to that of the blank control from the independent experiments shown in Table S1. The error bars represent the standard error of the mean.