TABLE 2.
Serum AST and ALT levels after LiCl treatment of K. pneumoniae infectiona
| Time (h) | AST level (U/liter) |
ALT level (U/liter) |
||||
|---|---|---|---|---|---|---|
| NK-9 | NK-9 + LiCl | LiCl | NK-9 | NK-9 + LiCl | LiCl | |
| 0 | 102 ± 18 | 114 ± 7 | 115 ± 5 | 43 ± 3 | 38 ± 8 | 41 ± 3 |
| 18 | 698 ± 36 | 188 ± 27b | 103 ± 8 | 375 ± 50 | 45 ± 10b | 38 ± 5 |
| 72 | 792 ± 85 | 220 ± 25b | 101 ± 7 | 412 ± 54 | 85 ± 13b | 42 ± 3 |
a
Groups of four mice were inoculated, via the intragastric route, with 5 × 108 K. pneumoniae NK-9 cells per mouse. LiCl (400 μg/ml) was administered immediately postinfection by addition to the drinking water. The mice were sacrificed at 0, 18, or 72 h postinfection, sera were collected, and AST and ALT levels were measured. Data are presented as mean ± standard deviation. The statistical analysis was performed using repeated-measures ANOVA.
b
P < 0.05, compared with results for NK-9-treated mice.