TABLE 1.
MIC distribution for pexiganan when tested against pathogens causing diabetic foot infections selected from the SENTRY Antimicrobial Surveillance Program in 2013
| Organism (no. of isolates tested) | No. of strains with the following MIC (μg/ml) (cumulative %): |
MIC50 (μg/ml) | MIC90 (μg/ml) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤4 | 8 | 16 | 32 | 64 | 128 | 256 | 512 | >512 | |||
| S. aureus (20) | 15 (75.0) | 5 (100.0) | 16 | 32 | |||||||
| MSSA (12) | 8 (66.7) | 4 (100.0) | 16 | 32 | |||||||
| MRSA (8) | 7 (87.5) | 1 (100.0) | 16 | ||||||||
| BHS (3)a | 2 (66.7) | 1 (100.0) | |||||||||
| E. faecium (1) | 1 (100.0) | 8 | |||||||||
| Enterobacteriaceae (15) | 10 (66.7) | 1 (73.3) | 4 (100.0) | 8 | >512 | ||||||
| E. coli (6) | 6 (100.0) | 8 | |||||||||
| K. pneumoniae (2) | 2 (100.0) | 8 | |||||||||
| IPP (3)b | 3 (100.0) | >512 | |||||||||
| Other (4)c | 2 (50.0) | 1 (75.0) | 1 (100.0) | 8 | |||||||
| P. aeruginosa (6) | 4 (66.7) | 2 (100.0) | 8 | ||||||||
| A. baumannii (1) | 1(100.0) | 8 | |||||||||
| All organisms (46) | 16 | 32 | |||||||||
a
BHS, beta-hemolytic streptococci (includes S. agalactiae [2 isolates] and S. pyogenes [1 isolate]).
b
IPP, indole-positive Proteae (includes M. morganii [2 isolates] and P. vulgaris [1 isolate]).
c
Other includes Citrobacter koseri (1 isolate), E. cloacae (2 isolates), and S. marcescens (1 isolate; MIC, >512 μg/ml).