TABLE 2.
Equations of the evaluated methods for the prediction of meropenem pharmacokinetic parameters in adult patients
| Study (reference), no. of patients in the study | Equationa |
|---|---|
| Noncompartmental analysis models | |
| Leroy et al. (11,13), n = 32 | CL (ml/min) = 1.85 · CLCR + 24.9; Vss (liters) = 0.264 · TBW if CLCR = >80 ml/min; Vss (liters) = 0.212 · TBW if CLCR is 30−80 ml/min; Vss (liters) = 0.342 · TBW if CLCR = <30 ml/min |
| Christensson et al. (12), n = 23 | CL (ml/min/1.73 m2) = 1.71 · CLCR + 14; Vss (liters) = 0.21 · TBW if CLCR = >80 ml/min/1.73 m2; Vss (liters) = 0.2 · TBW if CLCR = 30−80 ml/min/1.73 m2; Vss (liters) = 0.23 · TBW if CLCR = <30 ml/min/1.73 m2 |
| One-compartment population pharmacokinetic model | |
| Muro et al. (14), n = 68 | CL (liters/h) = 11.1 · (mSCR/0.7)−1; V (liters) = 33.6 |
| Two-compartment population pharmacokinetic models | |
| Crandon et al. (9), n = 21 | K (h−1) = 0.392 + 0.003 · CLCR; V1 (liters) = AdjBW · 0.239 |
| Li et al. (7), n = 79 | CL (liters/h) = 14.6 · (CLCR/83)0.62 · (AGE/35)−0.38; V1 (liters) = 10.8 · (TBW/70)0.99; V2 (liters) = 12.6 |
| Doh et al. (8), n = 59 | CL (liters/h) = 4.45 + 10.5 · (CLCR/138); V1 (liters) = 17 + 11.1 · EDEMA; V2 (liters) = 10.1 |
| Roberts et al. (10), n = 10 | CL (liters/h) = 13.6 · (6/CLCR); V1 = 7.9; V2 = 14.8 |
a
CL, meropenem plasma clearance; CLCR, creatinine clearance; Vss, steady-state volume of distribution; TBW, total body weight, mSCR, modified serum creatinine; V, volume of distribution for one-compartment model; K, elimination rate constant from the central compartment; V1, volume of distribution of the central compartment; V2, volume of distribution of the peripheral compartment; AdjBW, adjusted body weight; EDEMA, indicator for the presence (1) or absence (0) of edema.