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Characteristics of Amdr laboratory-selected E. coli mutants
| Gene | No. of mutants | No. of different mutationsa | MIC(s) |
|---|---|---|---|
| thrS | 4 | 4 | 16–48 |
| aspS | 7 | 6 (3 in promoter) | 12–16 |
| gltX | 2 | 2 | 16–32 |
| ppa | 3 | 2 | 96 |
| mrdA | 2 | 1 | 12–64 |
| ubiE | 1 | 12 | |
| ubiX | 1 | 32 | |
| ispA | 1 | 12 | |
| rplL | 1 | 8 | |
| rpoB | 1 | 32 | |
| spoT | 1 | 24 | |
| cysB | 1 | 24 |
For the specific mutations in these genes, see Table S1 in the supplemental material.
