TABLE 6.
MICs of antibioticsa for reconstructed Amdr mutants and E. coli MG1655
| Strain | Genotype | MIC (mg/liter) of: |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Amd | Mem | Ctx | Amp | Cip | Nit | Fof | Tmp | Sxt | Chl | Nal | Tet | Ery | ||
| DA5438b | Wild type | 0.125 | 0.023 | 0.064 | 2 | 0.016 | 2 | 0.5 | 0.125 | 0.047 | 6 | 3 | 1 | 16 |
| DA28432 | ppa (D11A) | 96 | 0.032 | 0.047 | 0.75 | 0.016 | 3 | 0.19 | 0.94 | 0.032 | 4 | 0.5 | 0.75 | 198 |
| DA28434 | aspS (P191S) | 24 | 0.047 | 0.047 | 2 | 0.016 | 3 | 0.094 | 0.125 | 0.032 | 6 | 3 | 0.5 | 64 |
| DA28436 | ubiE (delc bp 346–349 → FSd) | 12 | 0.023 | 0.032 | 1 | 0.016 | 2 | 0.094 | 0.75 | 0.064 | 1.5 | 3 | 0.5 | 64 |
| DA28438 | spoT (S305P) | 32 | 0.032 | 0.064 | 1.5 | 0.016 | 0.25 | 0.19 | 0.125 | 0.023 | 3 | 2 | 0.094 | 32 |
| DA28439 | cysB KOe | 32 | 0.064 | 0.047 | 2 | 0.023 | 1 | 0.5 | 0.38 | 0.064 | 4 | 3 | 0.75 | >256 |
| DA29703 | thrS (E519G) | 32 | 0.032 | 0.064 | 2 | 0.023 | 4 | 1 | 0.25 | 0.047 | 6 | 3 | 0.75 | 24 |
| DA29705 | mrdA (D389G) | 16 | 0.023 | 0.023 | 0.75 | 0.016 | 1.5 | 0.38 | 0.94 | 0.016 | 6 | 3 | 0.5 | 24 |
| DA29707 | ubiX (del bp 246 → FS) | 32 | 0.047 | 0.032 | 1 | 0.023 | 1 | 0.094 | 0.25 | 0.047 | 3 | 3 | 1 | 96 |
| DA29710 | rplL (promoter −10) | 48 | 0.032 | 0.047 | 0.5 | 0.023 | 2 | 0.125 | 0.125 | 0.032 | 4 | 3 | 0.75 | 24 |
| DA29712 | rpoB (H447L) | 48 | 0.047 | 0.064 | 2 | 0.023 | 4 | 0.064 | 0.094 | 0.047 | 4 | 3 | 0.75 | 16 |
| DA29715 | trxB (G37D) | 0.064 | 0.023 | 0.047 | 2 | 0.016 | 6 | 1 | 0.19 | 0.047 | 4 | 3 | 1 | 24 |
| DA29717 | mrdA (D389G) trxB (G37D) | 64 | 0.016 | 0.023 | 0.75 | 0.023 | 2 | 0.19 | 0.38 | 0.032 | 6 | 6 | 0.5 | 48 |
| DA30120 | gltX (D180G) | 24 | 0.047 | 0.032 | 1 | 0.016 | 0.75 | 0.25 | 0.094 | 0.032 | 4 | 2 | 0.5 | 96 |
| DA30122 | ispA (IS1 insertion) | 16 | 0.032 | 0.023 | 1 | 0.016 | 2 | 0.094 | 0.125 | 0.032 | 1 | 2 | 0.38 | 96 |
Mem, meropenem; Ctx, cefotaxime; Cip, ciprofloxacin; Nit, nitrofurantoin; Fof, fosfomycin; Tmp, trimethoprim; Sxt, trimethoprim-sulfamethoxazole; Nal, nalidixic acid; Ery, erythromycin.
E. coli MG1655.
del, deletion.
FS, frame shift.
KO, knockout.