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pVXc-486 had increased exposure in the lungs of infected mice compared to the levels of the parent (mesylate salt) compound VXc-486 and moxifloxacin (MXF). The dose administered is noted at the bottom of each group. Samples were collected 1 h (A) and 6 h (B) after administration of the compounds at the termination of the 4-week treatment model (described in the legend to Fig. 2), and lung concentrations were determined. Error bars show standard deviations.
