FIG 4.

pVXc-486 improved the bactericidal activities of antimycobacterial drugs. Mycobacterial burdens were measured by CFU counts from lung homogenates of M. tuberculosis-infected mice (H37Rv) and were assessed at the end of 8 weeks of treatment. Each compound was administered by the oral route once per day, 5 days per week, for 8 weeks at the following doses: pVXc-486, 100 mg/kg; isoniazid (INH), 10 mg/kg; rifampin (RIF), 10 mg/kg; pyrazinamide (PZA), 150 mg/kg; moxifloxacin (MXF), 100 mg/kg; ethambutol (EMB), 100 mg/kg; and amikacin (AMK), 30 mg/kg. Horizontal bars show mean results.