FIG 6.
pVXc-486 has activity comparable to that of isoniazid (INH) when used as a single agent and renders mice culture negative in combination with rifampin (RIF) in a mouse model of latent tuberculosis (TB) chemotherapy. BALB/c mice were immunized with Mycobacterium bovis bacillus Calmette-Guérin (BCG) 5 weeks prior to being infected with M. tuberculosis (H37Rv). Mice were then treated 5 weeks later for one or two months with pVXc-486 and control drugs. The M. tuberculosis H37Rv lung log10 CFU counts were 4.13 ± 0.13 (mean ± SD) at the start of drug treatment (early control). The dotted lines represent the lower limit of detection of the assay. Horizontal bars show mean results.