. 2015 Feb 11;59(3):1455–1465. doi: 10.1128/AAC.04347-14

TABLE 3.

VXc-486 inhibited M. tuberculosis replication in macrophages and in a low-oxygen-recovery assay^a

Compound	IC₅₀ (μg/ml) for indicated isolate in macrophages		IC₅₀ (μg/ml) for H37Rv in LORA
Compound	H37Ra	CDC1551	IC₅₀ (μg/ml) for H37Rv in LORA
VXc-486	0.012	0.115	0.252
RIF	0.008	0.040	0.160
MXF	0.120	0.216	1.600
GAT	0.530	2.500	8.807

Rifampin (RIF), moxifloxacin (MXF), and gatifloxacin (GAT) were used as comparator compounds. The low-oxygen-recovery assay (LORA) was carried out in broth culture without macrophages. The reporter genes used encoded luciferase (for H37Ra), mCherry (for CDC1551), or green fluorescent protein (for H37Rv).