TABLE 4.
TRL345 tissue reactivity profile
| Tissue | % stained cells (degree of staining), no. of donors/total donors by concna: |
Notes | |
|---|---|---|---|
| 1 μg/ml | 20 μg/ml | ||
| Positive control | 100 (++++) | 100 (++++) | HEK293(gB) |
| Negative control | 0 (−−) | 0 (−−) | HEK293(vector) |
| Skin | <25 (++) cytoplasmic, 1/3 | 25–75 (+++) cytoplasmic, 1/3 | Squamous epithelium |
| Colon | Negative | <25 (++) cytoplasmic, 2/3 | Intestinal epithelium |
| Small intestine (adult) | Negative | 25–50 (++) cytoplasmic, 3/3 | Intestinal epithelium |
| Small intestine (fetal) | 25–50 (++) cytoplasmic, 1/3 | 25–75 (+++) cytoplasmic, 3/3 | Intestinal epithelium |
| Pancreas (adult) | 25–75 (+++) cytoplasmic, 1/3 | 25–75 (+++) cytoplasmic, 2/3 | Duct epithelium |
| Pancreas (fetal) | Negative | 25–50 (+) cytoplasmic, 2/2 | Acinar epithelium |
| Othersb | Negative | Negative | |
a
Intensity of stain: +, light; ++, light to moderate; +++, moderate; ++++, dark.
b
Others include adrenal, bladder, white blood cells, blood vessels (endothelium), bone marrow, breast, cerebellum, cerebral cortex, eye, fallopian tube, heart, kidney, liver, lung, lymph node, muscle (striated), nerve (peripheral), parathyroid, parotid (salivary gland), pituitary, placenta, prostate, spinal cord, spleen, stomach, testis, thymus, thyroid, tonsil, ureter, uterus (cervix and endometrium).