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. 2015 Feb 12;9:42. doi: 10.3389/fnins.2015.00042

Figure 2.

Figure 2

Relative changes in NAc [glucose] induced by cocaine injections assessed at high temporal resolution (2-s bins). Top graphs (A,C,E,G) show mean ± SEM changes in relative currents (nA) detected by Glucose and Null sensors. Bottom graphs (B,D,F,H) show mean ± SEM changes in [glucose] (μM) as a difference between active and null sensors. Two vertical hatched lines (at 0 and 20) marked the onset and offset injection. Horizontal dotted lines show basal levels (= 0 nA and μM). After cocaine injections, the Glucose and Null currents differed significantly (A 1: Glucose/Null [180 s, F(1, 11) = 6.97], interaction [180 s, F(90, 990) = 2.88]; C 2: Interaction [180 s, F(90, 990) = 1.44]; E 3: Glucose/Null [180 s, F(1, 11) = 8.31], interaction [153.5 s, F(77, 847) = 1.31]; G 4: Glucose/Null [47.5 s, F(1, 11) = 4.69], interaction [180s, F(90, 990) = 3.58], all p < 0.05), resulting in a significant [glucose] change for each cocaine injection during the entire analysis window [F(6, 546) = 3.47, 1.69, 1.37, and 4.31, all p < 0.05]. Concentration values significantly different from baseline (Fisher test) are shown as filled symbols. Right panel (I) shows mean ± SEM values of glucose responses induced by cocaine injections assessed by area under the curve for 30 s after the injection onset (n.s.).