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. 2015 Feb 12;9:41. doi: 10.3389/fnins.2015.00041

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Copyright © 2015 Schneeberger, Gomez-Valadés, Ramirez, Gomis and Claret.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Canonical miRNA biogenesis. Schematic representation of the Dicer-dependent miRNA generation pathway. miRNA genes are transcribed by RNA polymerase II, followed by nuclear processing by the microprocessor complex (consitituted by DGCR8 and Drosha), cytoplasmatic export by Exportin 5 and Dicer-mediated processing. The miRNA duplex is then released and loaded into the RISC. The “passenger” strand is degraded and the so-called “guide” miRNA will interact with the target mRNA causing translational repression or degradation.