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. 2015 Jan 24;15(1):1. doi: 10.1186/s12935-015-0156-6

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© Taylor et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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FOXO3a regulation by Akt. Growth factors/hormone stimulate PI3k phosphorylation of Akt, FOXO3a is phosphorylated by Akt, 14-3-3 also binds FOXO3a DNA binding sites, further preventing its activity in the nucleus. It is then tagged for degradation via ubiquitination and then degraded in a proteasome. Adapted from (Wilson, 2009 [49]).