Table 2.

PI3k inhibition causes FOXO3a activation in breast cancer cells

First author (Year)	Treatment	Effect on FOXO3a (Activates/Inactivates)	Cellular effects
Espinoza (2011) [25]	Zoledronic acid (ZOL)	Activates in MDA-MB-231 and MCF-7 measured by nuclear translocation of FOXO3a.	Inhibited proangiogenic factor, CCN1 in TNBC
Guo (2004) [34]	Wortmannin, EGCG	Activates in MCF-7 and ZR-75 cells; and Hs578T and MDA-MB-231 cells, measured as FOXO3a expression and nuclear translocation.	Increased ER expression