Table 4.

FOXO3a activation in breast cancer cells increases apoptosis

First author (Year)	Treatment	Effect on FOXO3a (Activates/Inactivates)	Cellular effects
Kong (2010) [35]	miR-155	Inhibits in BT-474 measured by protein expression.	Decreased Bim and p27 expression decreased apoptosis.
Kong (2012) [36]	AZD6244, indirectly as an ATP-uncompetitive inhibitor of MEK ½	Activates FOXO3a in MTDH knock-down, AZD6244 resistant lines.	Increased apoptosis.
Lam (2012) [37]	Aqueous extract of Fagonia	Activates FOXO3a measured by Western blot in MCF7 and MDA231.	Cell cycle arrest and apoptosis.
Lin (2010) [38]	miR-96	Inhibits in BT549, ZR-75-30, Bcap37, MDA-MB231, MDA-MB435, MCF-7, SKBR3 measured as FOXO3a expression and by reporter assay.	Down-regulation of p21 cip1, p27 kip1, CDK and cyclin 1.
Liu (2012) [39]	Arsenic trioxide	Activates in MCF7 measured as nuclear translocation and expression.	Decreased IKKB.
			Increased apoptosis.
Stan (2008) [40]	Withaferin.	Activates in MCF-7 (estrogen-responsive) and MDA-MB-231.	Increased Bim expression.
			Increased apoptosis.