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. 2015 Jan 29;2015:687162. doi: 10.1155/2015/687162

Figure 1.

Figure 1

NFV inhibits production of infectious HSV-1 through a mechanism distinct from that of acyclovir and does not readily select for antiviral resistance in vitro. HSV-1 was passaged four times in HF in the presence of either 5 μM NFV or 1 μM acyclovir, the approximate IC50 of each drug. Virus passaged in acyclovir showed increased resistance to inhibition by acyclovir but was inhibited by NFV similarly to the control HSV-1 isolate. In contrast, passage in the presence of NFV did not result in a significant change in susceptibility to either drug. Shown are the results from three separate experiments.