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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Biochem J. 2015 Jan 1;465(1):63–78. doi: 10.1042/BJ20140923

Figure 10. Superimposition of UNC-60A, UNC-60B and LdCof on HsCof in the structure of HsCof/F-actin.

Figure 10

To model the binding of different ADF/cofilins with F-actin, the structures of UNC-60A, UNC-60B and LdCof were superimposed on the HsCOF in the cryo-electron microscopy structure of human cofilin decorated F-actin to observe the binding of these proteins on F-actin. (A) Overlays of structure of unc-60a with cryoelectron microscopy structure of HsCof with F-actin. (B) Overlay of structure of UNC-60B and LdCOF on HsCof/F-actin. In overlays, actin protomers are shown in different colors. Structure of HsCof, UNC-60A, UNC-60B and LdCof are shown in magenta, green, red and cyan colors, respectively. ADF/cofilins are shown in cyan color, residues of F-loop showing motion on nanaosecond-picoseconds are shown in blue color. Structure of HsCof was omitted from overlays of UNC-60B and LdCOF for clearity.