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. Author manuscript; available in PMC: 2015 Dec 15.
Published in final edited form as: Cancer Res. 2014 Oct 27;74(24):7217–7228. doi: 10.1158/0008-5472.CAN-14-0505

Fig. 3. Increased tyrosine phosphorylations in receptor tyrosine kinase (RTK) after dasatinib exposure.

Fig. 3

A: Protein-protein interaction (PPI) network composed of dasatinib-regulated pY proteins identified from both H2286 and HCC366 cells. Each protein was annotated based on its functional classification, with PPI then mapped utilizing BisoGenet Cytoscape plug-in. Increased tyrosine phosphorylation of EGFR, IGF-1R, and ERBB2 and decreased tyrosine phosphorylation of SRC and LYN are presented in bigger nodes. Edges connected to EGFR, IGF-1R and ERBB2 are shown in red, with others in gray. “Undetermined” signifies pY peptides showing conflicting direction (increased versus decreased) in the two cell lines. B: Extracted ion chromatogram (EIC) for pY peptides corresponding to RTK. Two-sample t-test was performed to address significant difference in EIC between control and dasatinib treatment.