Table 2.
Range of Positivity in Organs from B6C3F1 Mice 179 Days After Intravenous Administration of Toca 511
| Organ | No. of positive mice/total no. of mice | Positivity (copies/μg) | Low | Medium | High |
|---|---|---|---|---|---|
| Blood | 20/20 | 199–14,823 | 20 | 0 | 0 |
| Cerebellum | 0/20 | – | 0 | 0 | 0 |
| Left cerebrum | 1/20 | 88 | 1 | 0 | 0 |
| Right cerebrum | 1/20 | 75 | 1 | 0 | 0 |
| Lower spinal cord | 3/20 | 101–160 | 3 | 0 | 0 |
| Upper spinal cord | 1/20 | 76 | 1 | 0 | 0 |
| Bone marrow | 19/20 | 109–3,679 | 19 | 0 | 0 |
| Lymph node | 19/20 | 197–17,916 | 18 | 1 | 0 |
| Spleen | 20/20 | 244–29,413 | 17 | 3 | 0 |
| Thymus | 19/20 | 400–276,846 | 17 | 2 | 0 |
| Heart | 9/20 | 97–4,110 | 9 | 0 | 0 |
| Lung | 17/20 | 111–4,843 | 17 | 0 | 0 |
| Esophagus | 14/20 | 76–6,459 | 14 | 0 | 0 |
| Esophagus (lower) | 16/20 | 221–22,802 | 14 | 2 | 0 |
| Intestine | 14/20 | 78–1,993 | 14 | 0 | 0 |
| Liver | 16/20 | 71–11,534 | 16 | 0 | 0 |
| Salivary gland | 18/20 | 90–5,149 | 18 | 0 | 0 |
| Kidney | 8/16 | 58–2,925 | 8 | 0 | 0 |
| Ovary | 18/20 | 81–18,114 | 17 | 1 | 0 |
| Urine | 0/14 | – | 0 | 0 | 0 |
| Skin | 5/20 | 127–3,661 | 5 | 0 | 0 |