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. 2015 Feb 1;22(2):85–110. doi: 10.1089/cmb.2014.0274

FIG. 1.

FIG. 1.

An example of minimum knockout for multiple networks (MKMN) problem. MKMN is a problem to find the minimum number of reactions whose inhibition makes the target compound nonproducible in N1 but producible in N2. (A) The MKMN solution for this example is {r3}, whose inhibition prevents production of vc9 in N1 but not in N2; (B) r1 of N1 in Figure 1A is decomposed into r1 and s1.