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Example for MKMN-EM
| N1 | N2 | ||
|---|---|---|---|
| EM1 | r1, r2, r4 | EM5 | r1, r2, r7 |
| EM2 | r1, r3, r6 | EM6 | r2, r3, r4 |
| EM3 | r2, r4, r5 | EM7 | r4, r5 |
| EM4 | r5, r7 | ||
After obtaining the EMs that produce the target compound using CellNetAnalyzer, MKMN-EM can be formalized by ILP. MKMN-EM, minimum knockout for multiple reactions in the elementary mode model; EM, elementary mode; ILP, integer linear programming.
