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. Author manuscript; available in PMC: 2015 Feb 12.
Published in final edited form as: Gastroenterology. 2011 Jul 18;141(4):1451–1462.e6. doi: 10.1053/j.gastro.2011.07.003

Figure 3.

Figure 3

Cells within the ductal compartment are highly proliferative in regenerating PdxCre;R26DTRpancreata. (A) Quantification (percent) of proliferating DBA+, amylase+, or insulin+ cells. PHH3, phospho-histone H3. Wild type (WT) is an age-matched adult control pancreas. (B) Pulse-chase BrdU experiments. On day 1 (pulse), the duct-like structures were the main epithelial cells incorporating BrdU. On day 10 (chase), presence of (C) insulin+/BrdU+ cells and (D) amylase+/BrdU+ cells suggested that these cells or their precursors must have been proliferating mmediately after injury. (E) Several amylase+/BrdU+ cells were found within both the small and large duct-like structures, further supporting the hypothesis that the main source of regenerating acinar cells resides in the ducts rather than in proliferating residual Cre− acinar cells. Scale bars = 20 μm.