Table I.

Clinical questions used to structure the evidence review for the management and treatment of atopic dermatitis with topical therapies

What is the effectiveness of non-pharmacological interventions such as moisturizers, prescription emollient devices, bathing practices and oils, and wet-wraps for the treatment of atopic dermatitis? What is the efficacy, optimal dose, frequency of application, and adverse effects of the following agents used as monotherapy or in combination with other topical agents for the treatment of atopic dermatitis? ▪ Topical corticosteroids ▪ Topical calcineurin inhibitors ▪ Topical antimicrobials/antiseptics ▪ Topical antihistamines ▪ Others (e.g. coal tar, phosphodiesterase inhibitors)