Table 1.
Novel pathways that may be involved in IL-2 signaling in human primary NK cells and names of IL-2 regulated proteins that are known to be the components of these pathways.
| Ubiquitin proteasome pathway (11) |
| 26S proteasome non-ATPase regulatory subunit 1 (PSMD1) |
| 26S proteasome non-ATPase regulatory subunit 3 (PSMD3) |
| 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) |
| 26S proteasome non-ATPase regulatory subunit 7 (PSMD7) |
| 26S proteasome non-ATPase regulatory subunit 11 (PSMD11) |
| 26S proteasome non-ATPase regulatory subunit 12 (PSMD12) |
| NEDD8-activating enzyme E1 catalytic subunit (UBA3) |
| 26S protease regulatory subunit 4 (PRS4) |
| Ubiquitin-conjugating enzyme E2 L3 (UB2L3) |
| Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UBP5) |
| SUMO-activating enzyme subunit 1 (SAE1) |
| Integrin signaling pathway (9) |
| Integrin beta-7 (ITB7) |
| Dual specificity mitogen-activated protein kinase kinase 1 (MP2K1) |
| Integrin alpha-X (ITAX) |
| Ras-related C3 botulinum toxin substrate 3 (RAC3) |
| ADP-ribosylation factor 3 (ARF3) |
| Rho-related GTP-binding protein RhoB (RHOB) |
| Actin, gamma-enteric smooth muscle (ACTH) |
| Proto-oncogene tyrosine-protein kinase Fyn (FYN) |
| Integrin alpha-D (ITAD) |
| PDGF signaling pathway (8) |
| Dual specificity mitogen-activated protein kinase kinase 1 (MP2K1) |
| Signal transducer and activator of transcription 1-alpha/beta (STAT1) |
| Signal transducer and activator of transcription 3 (STAT3) |
| Signal transducer and activator of transcription 4 (STAT4) |
| Ras-related protein Rab-11B (RB11B) |
| Rho GTPase-activating protein 4 (RHG04) |
| Rho-related GTP-binding protein RhoB (RHOB) |
| Ribosomal protein S6 kinase alpha-3 (KS6A3) |
| EGF receptor signaling pathway (7) |
| Dual specificity mitogen-activated protein kinase kinase 1 (MP2K1) |
| Signal transducer and activator of transcription 1-alpha/beta (STAT1) |
| Signal transducer and activator of transcription 3 (STAT3) |
| Signal transducer and activator of transcription 4 (STAT4) |
| Ras-related C3 botulinum toxin substrate 3 (RAC3) |
| Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2AB) |
| Mitogen-activated protein kinase 14 (MK14) |
| Wnt signaling pathway (6) |
| Beta-arrestin-1 (ARRB1) |
| Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2AB) |
| Histone deacetylase 1 (HDAC1) |
| C-terminal-binding protein 2 (CTBP2) |
| Nuclear factor of activated T-cells, cytoplasmic 2 (NFAC2) |
| Actin, gamma-enteric smooth muscle (ACTH) |