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. 2015 Feb 12;10(2):e0117356. doi: 10.1371/journal.pone.0117356

Fig 3. R1R2 decreases collagen content in the ligated vessel.

Fig 3

(A) Immunohistochemistry (IHC) for collagen type I 14 days post-surgery. Bar, 100 μm. (B) Quantification of immunostaining intensity of collagen I in the intima-media area 7 (Sham: n = 6, Scrambled: n = 6, R1R2: n = 6) and 14 days (Sham: n = 6, Scrambled: n = 6, R1R2: n = 5) after the ligation. (C) Collagen content was biochemically measured by hydroxyproline assay in the carotid artery 14 days after ligation. n = 3 for each experimental group. * indicates p<0.05, ** p< 0.01 and *** p< 0.001.