Table 4.
Genotype at ABCC2 and parameters of proximal kidney tubular dysfunction and estimated glomerular filtration rate of 30 patients treated with adefovir dipivoxil n (%)
| Genotype CC or CT | Genotype TT | P value | |
| (n = 26) | (n = 4) | ||
| Serum phosphate (mmol/L) | 0.86 ± 0.21 | 1.00 ± 0.25 | NS |
| TmP/GFR (mmol/L) | 0.73 ± 0.28 | 0.95 ± 0.42 | NS |
| Serum uric acid (umol/L) | 267.2 ± 120.3 | 258.7 ± 26.4 | NS |
| FEUA (%) | 16.6 ± 14.6 | 9.5 ± 1.6 | 0.025 |
| UBCR (mg/gCr) | 996.3 (68.2-14555.9) | 201.4 (81.5-497.7) | 0.038 |
| Phosphate diabetes | 8 (30.8) | 1 (25.0) | NS |
| Renal hypouricemia | 10 (38.5) | 0 | NS |
| β2-microglobulinuria | 14 (53.8) | 1 (25.0) | NS |
| Nondiabetic glucosuria | 5 (19.2) | 0 | NS |
| Metabolic acidosis | 2 (7.7) | 0 | NS |
| eGFR (mL/min per 1.73 m2) | 62.8 ± 17.6 | 64.4 ± 2.1 | NS |
Data are shown as mean ± SD, percentage, or geometric mean ± SD. Overall P values were calculated by unpaired t-test or χ2-test in comparison between ABCC2 -24 genotype CC/CT and genotype TT. TmP/GFR: Tubular maximum for phosphate corrected for glomerular filtration rate; FEUA: Fractional excretion of uric acid; UBCR: Urine β2-microglobulin-creatinine ratio; eGFR: Estimated glomerular filtration rate; NS: Not significant.