Table 1.
Variable | Primary hepatectomy (n = 406) | Secondary hepatectomy (n = 55) | P value1 |
Sex (M/F) | 266:140 | 36:19 | 0.99 |
Median age (yr) (range) | 59.5 (26-80) | 58 (36-80) | 0.95 |
Number of CRLM (median, range) | 1 (1-8) | 1 (1-4) | 0.01 |
CRLM size (median, range) | 2.4 (0.2-7.5) | 2.4 (1.0-7.5) | 0.85 |
Liver metastases | |||
Synchronous | 279 (69) | 39 (71) | 0.74 |
Metachronous | 127 (31) | 16 (29) | |
CRLM number | |||
Single | 232 (57) | 41 (75) | 0.014 |
Multiple | 174 (43) | 14 (25) | |
CRLM treatment | |||
Resection | 324 (80) | 25 (45) | < 0.001 |
RFA | 57 (14) | 29 (53) | |
Both | 25 (6) | 1 (2) | |
T stage | |||
T1 T2 T3 | 364 (90) | 47 (85) | 0.35 |
T4 | 42 (10) | 8 (15) | |
N stage | |||
N0 | 117 (29) | 13 (24) | 0.42 |
N1 or N2 | 289 (71) | 42 (76) | |
Histological differentiation2 | |||
High grade | 367 (90) | 53 (96) | 0.21 |
Low grade | 39 (10) | 2 (4) | |
Lymphatic invasion | |||
(-) | 172 (42) | 16 (29) | 0.02 |
(+) | 129 (32) | 26 (47) | |
Vascular invasion | |||
(-) | 168 (41) | 29 (53) | 0.14 |
(+) | 102 (25) | 10 (18) | |
Perineural invasion | |||
(-) | 191 (47) | 20 (36) | 0.38 |
(+) | 74 (18) | 11 (22) | |
Chemotherapy | |||
Yes | 373 (92) | 50 (91) | 0.79 |
No | 33 (8) | 5 (9) |
χ2 test, Fisher’s exact test, or Mann Whitney U test;
High grade: well or moderately differentiated, Low grade: poorly differentiated or mucinous carcinoma. CRLM: Colorectal liver metastases.