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. Author manuscript; available in PMC: 2015 Feb 12.
Published in final edited form as: Biochim Biophys Acta. 2013 Nov 4;1842(2):208–219. doi: 10.1016/j.bbadis.2013.10.016

Table 2.

a. Comparison of Gene Expression Differences in Canonical Pathways for L Cybrids versus H Cybrids as Determined by IPA Summary Program Analyses of Affymetrix Human U133 Plus 2.0 Array
Ingenuity Canonical Pathways P-value Ratio Molecules
Complement System 0.00298 5/35 (0.143) C1R, CFD, C3, C1S, CFH
CCR3 Signaling in Eosinophils 0.00688 9/126 (0.071) GNAI3, PLA2G4A, GNB4, MPRIP, PIK3C2A, PLA2G4C, GNB1L, PRKD3, LIMK1
Dermatan Sulfate Biosynthesis (Late Stages) 0.00794 5/47 (0.106) CHST2, CHST5, SULT1C2, HS3ST1, CHST15
Chondroitin Sulfate Biosynthesis (Late Stages) 0.00975 5/54 (0.093) CHST2, CHST5, SULT1C2, HS3ST1, CHST15
b. Details of the Genes Most Differentially Expressed in the Canonical Pathways as Identified by the Affymetrix Human U133 Plus 2.0 Array (see Table 2a)
Probe Set ID Represent ative Public ID Gene Title Gene Symbol CYBD -L Signal CYBD -H Signal L vs H (Fold)
Complement Pathway
205382_s_at NM_00192 8 complement factor D (adipsin) CFD 110.22 28 221.97 49 −2.014
217767_at NM_00006 4 complement component 3 C3 47.807 12 266.43 35 −5.573
208747_s_at M18767 complement component 1, s subcomponent C1S 373.55 14 1077.6 74 −2.885
213800_at X04697 complement factor H CFH 374.22 68 731.56 13 −1.955
233645_s_at AK024084 complement component 1, r subcomponent-like C1RL 34.922 33 80.276 31 −2.299
212067_s_at AL573058 complement component 1, r subcomponent C1R 462.33 73 921.95 −1.994
CCR3 Signaling in Eosinophils
201179_s_at J03005 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 GNAI 3 1984.7 61 964.71 7 2.057
210145_at M68874 phospholipase A2, group IVA (cytosolic, calcium-dependent) PLA2 G4A 508.06 08 239.03 16 2.125
225710_at H99792 guanine nucleotide binding protein (G protein), beta polypeptide 4 GNB 4 2083.3 21 1604.4 51 1.298
238330_s_at BE545235 Myosin phosphatase Rho interacting protein MPRI P 45.435 6 38.304 87 1.186
213070_at AV682436 phosphoinositide-3-kinase, class 2, alpha polypeptide PIK3 C2A 3398.1 76 3108.4 79 1.093
1554810_at BC017956 phospholipase A2, group IVC (cytosolic, calcium-independent) PLA2 G4C 2.8145 04 3.7450 29 −1.331
204357_s_at NM_00231 4 LIM domain kinase 1 LIMK 1 364.53 68 172.30 25 2.116
Dermatan Sulfate Biosynthesis (late stages)
203921_at NM_00426 7 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 CHST 2 172.48 77 574.86 35 −3.333
221164_x_at NM_01212 6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 CHST 5 166.99 94 66.774 11 2.501
205342_s_at AF026303 sulfotransferase family, cytosolic, 1C, member 2 SULT 1C2 1550.9 49 727.04 83 2.133
213991_s_at BF940710 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 HS3S T1 8.1710 75 11.568 58 −1.416
203066_at NM_01486 3 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 CHST 15 123.38 05 259.39 76 −2.102
Chondroitin Sulfate Biosynthesis (late stages)
203921_at NM_00426 7 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 CHST 2 172.48 77 574.86 35 −3.333
221164_x_at NM_01212 6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 CHST 5 166.99 94 66.774 11 2.501
205342_s_at AF026303 sulfotransferase family, cytosolic, 1C, member 2 SULT 1C2 1550.9 49 727.04 83 2.133
213991_s_at BF940710 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 HS3S T1 8.1710 75 11.568 58 −1.416
203066_at NM_01486 3 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 CHST 15 123.38 05 259.39 76 −2.102