Fig. 2.

p38 is involved in M.abs-mediated HO-1 induction signal transduction pathway. (A) TPA-differentiated THP-1 cells were infected with M.abs for 1 h, washed and incubated in media as shown in materials and methods. Cells were collected at different time points. Phosphorylated and total forms of p38MAPK were determined by immunoblotting. (B) Addition of the p38 inhibitors; SB203580 and SB202190 reduced HO-1 induction by M.abs.