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. 2015 Feb 4;15(1):11. doi: 10.1186/s12935-015-0159-3

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© Xu et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Silencing Arf6 reduces internalization of E -cadherin by EGF. (A&B) The expression of Arf6 after treatment with Arf6 siRNA. Total protein extracts from T47D (A) and MCF-7 (B) cells transfected with Arf6 siRNA or control siRNA (mock) were analyzed by immunoblotting for Arf6. GAPDH was used a loading control. (C&D) Expression of biotin-labeled E-cadherin was determined by internalization assays in the T47D (C) and MCF-7 (D) cells transfected with siRNA for Arf6. **: P < 0.01, referring to the difference between cells treated with and those without EGF. ^##: P < 0.01, referring to the difference between cells transfected with Arf6 siRNA plus EGF and the cells transfected with control siRNA plus EGF.