Table 5.
Various inflammatory factors before and after operation between the two studied groups
| Study group (N = 44) | control group (N = 41) | Difference 1,2 [95% C.I.] | P | |
|---|---|---|---|---|
| IL-6 (pg/mL) | ||||
| Day -1 | 7.13 ± 19.22 | 21.16 ± 59.75 | -13.724 [-32.496; 5.048] | 0.150 |
| Before surgery | 11.78 ± 21.30 | 26.01 ± 52.29 | -13.793 [-30.417; 2.824] | 0.103 |
| After surgery | 126.56 ± 103.68 | 133.17 ± 109.18 | -8.867 [-55.025; 37.291] | 0.703 |
| Day 1 | 99.40 ± 88.12 | 99.88 ± 97.50 | -0.958 [-41.005; 39.089] | 0.962 |
| Day 3 | 35.72 ± 57.33 | 41.22 ± 63.48 | -5.808 [-31.878; 20.262] | 0.659 |
| Day 7 | 23.58 ± 45.25 | 26.44 ± 53.61 | -2.741 [-24.202; 18.719] | 0.800 |
| Follow up3 | 16.25 ± 19.46 | 22.15 ± 47.82 | -5.810 [-21.446; 9.826] | 0.462 |
| Day 7 – Day -1 | 16.45 ± 28.31 | 5.27 ± 53.00 | 6.648 [-10.876; 24.172] | 0.453 |
| CRP (mg/dL) | ||||
| Day -1 | 0.96 ± 1.80 | 2.04 ± 5.65 | -1.069 [-2.857; 0.720] | 0.238 |
| Before surgery | 1.13 ± 1.79 | 1.75 ± 3.91 | -0.615 [-1.919; 0.688] | 0.350 |
| After surgery | 1.52 ± 1.70 | 1.94 ± 3.49 | -0.405 [-1.576; 0.765] | 0.493 |
| Day 1 | 8.31 ± 4.68 | 9.17 ± 4.80 | -0.837 [-2.877; 1.202] | 0.416 |
| Day 3 | 10.20 ± 5.93 | 12.24 ± 7.52 | -2.043 [-4.792; 0.885] | 0.169 |
| Day 7 | 4.92 ± 4.60 | 4.95 ± 5.12 | -0.040 [-2.152; 2.072] | 0.970 |
| Follow up3 | 3.88 ± 4.72 | 5.23 ± 6.83 | -1.304 [-3.804; 1.196] | 0.303 |
| Day 7 – Day -1 | 3.95 ± 4.89 | 3.01 ± 7.11 | -0.004 [-2.155; 2.148] | 0.997 |
| TNF-α (pg/mL) | ||||
| Day -1 | 2.00 ± 2.07 | 3.38 ± 6.59 | -1.395 [-3.474; 0.685] | 0.186 |
| Before surgery | 2.01 ± 1.09 | 3.17 ± 6.71 | -1.176 [-3.224; 0.872] | 0.257 |
| After surgery | 1.60 ± 1.43 | 3.05 ± 5.23 | -1.475 [-3.096; 0.147] | 0.074 |
| Day 1 | 1.72 ± 1.67 | 2.88 ± 4.01 | -1.174 [-2.485; 0.137] | 0.079 |
| Day 3 | 2.12 ± 2.24 | 3.33 ± 4.14 | -1.237 [-2.653; 0.180] | 0.086 |
| Day 7 | 2.55 ± 2.30 | 3.70 ± 5.83 | -1.169 [-3.061; 0.724] | 0.223 |
| Follow up3 | 2.42 ± 2.09 | 3.83 ± 5.44 | -1.424 [-3.182; 0.334] | 0.111 |
| Day 7 – Day -1 | 0.55 ± 1.38 | 0.38 ± 1.63 | 0.002 [-0.609; 0.612] | 0.995 |
| PCT (ng/mL) | ||||
| Day -1 | 0.06 ± 0.03 | 0.15 ± 0.37 | -0.085 [-0.197; 0.027] | 0.133 |
| Before surgery | 0.13 ± 0.15 | 0.16 ± 0.25 | -0.029 [-0.118; 0.060] | 0.518 |
| After surgery | 0.29 ± 0.31 | 0.32 ± 0.31 | -0.029 [-0.163; 0.105] | 0.671 |
| Day 1 | 0.65 ± 0.82 | 0.80 ± 1.29 | -0.148 [-0.612; 0.316] | 0.528 |
| Day 3 | 0.29 ± 0.29 | 0.41 ± 0.60 | -0.125 [-0.325; 0.075] | 0.216 |
| Day 7 | 0.14 ± 0.15 | 0.24 ± 0.48 | -0.097 [-0.249; 0.056] | 0.211 |
| Follow up3 | 0.12 ± 0.09 | 0.68 ± 1.88 | -0.557 [-1.120; 0.006] | 0.053 |
| Day 7 – Day -1 | 0.08 ± 0.15 | 0.09 ± 0.62 | -0.101 [-0.256; 0.055] | 0.202 |
CRP: C-reactive protein; TNF-α: tumor necrosis factor-α; PCT: procalcitonin.
1Difference = [study group] - [control group].
2ANOVA incorporating center effect and their respective baseline as covariate; Difference and 95% C.I. was based on the LS-mean.
3Follow up was defined as 30 days after last treatment.